In light-weight of these observations, sirtuins are recognised as novel regulators of immuno-metabolism in humans. Aside from SIRT1, SIRT2 has been a short while ago linked to cytoskeleton transforming and activation of NLRP3 in intracellular pathways[117]. Apart from the activation of innate immunity, the contribution of adaptive immune cells in https://www.directivepublications.org/journal-of-diabetology-research/