DNA ligases seal five′-PO4 and 3′-OH polynucleotide finishes through three nucleotidyl transfer ways involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are crucial guardians of genomic integrity, and ligase dysfunction underlies human genetic sickness syndromes. Crystal structures of DNA ligases certain to nucleotide and nucleic acid substrates have illuminated how https://christopherx567ohb1.csublogs.com/profile